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| Time | Teams | Pick | Score |
| 10 a.m. | Buffalo at New York Jets |  | 19-13 |
| | Jets are 7-1 vs. the Bills over the previous four seasons, including the last five meetings. |
|
| 10 a.m. | Indianapolis at Chicago |  | 24-20 |
| | Don't worry Andrew Luck, even Peyton Manning lost his first four starts. |
|
| 10 a.m. | New England at Tennessee |  |
| Ch. 7 | Jake Locker gets his first NFL start against opponent that's won eight straight season-openers. |
|
| 10 a.m. | Philadelphia at Cleveland |  | 27-13 |
| | Browns have lost last seven straight season-openers, longest active streak in the league. |
|
| 10 a.m. | St. Louis at Detroit |  | 31-24 |
| Ch. 13 | Who's No. 1? QBs Matthew Stafford (Lions) and Sam Bradford (Rams) were both drafted first. |
|
| 10 a.m. | Atlanta at Kansas City |  | 24-20 |
| | Falcons coming off fourth straight winning season, longest stretch of success in franchise history. |
|
| 10 a.m. | Jacksonville at Minnesota |  | 17-15 |
| | There are classic quarterback matchups, and Blaine Gabbert vs. Christian Ponder is not one of them. |
|
| 10 a.m. | Washington at New Orleans |  | 34-13 |
| | Big Easy relishes a respite from the hardest of offseasons. |
|
| 10 a.m. | Miami at Houston |  | 27-20 |
| | When it comes to Houston, Miami has a problem. Dolphins 0-6 vs. Texans. |
|
| 1:25 p.m. | Seattle at Arizona |  | 16-13 |
| Ch. 13 | Seahawks have lost last 5 road openers. None of those were against John Skelton, though. |
|
| 1:25 p.m. | San Francisco at Green Bay |  | 31-26 |
| | Packers have won 9 in a row vs. 49ers, and Mike McCarthy is 5-1 as Packers coach in Week 1. |
|
| 1:25 p.m. | Carolina at Tampa Bay |  | 20-29 |
| | Bucs lost their last 10 in 2011, longest active losing streak in the league. |
|
| 5:20 p.m. | Pittsburgh at Denver |  | 34-31 |
| Ch. 5 | If Tim Tebow could beat the Steelers, just what is Peyton Manning going to do? |
|
| Monday's games |
| 4 p.m. | Cincinnati at Baltimore |  | 17-12 |
| ESPN | John Harbaugh is 4-0 in season-openers as the Ravens' head coach. |
|
| 7:15 p.m. | San Diego at Oakland |  | 37-31 |
| ESPN | Raiders have won three of last four vs. Chargers, but had lost their last 13 vs. San Diego prior to that. |
|
162-81 (.667).
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