The Seahawks' schedule includes two prime-time appearances, a game against Buffalo that will be played in Toronto, and a two-game homestand against division opponents San Francisco and St. Louis to conclude the regular season.
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| | Opponent | Date | Time |
| Week 1 |  | at Arizona Cardinals | Sunday, Sept. 9 | 1:15 p.m. |
| Storyline: Seattle has not won its first road game of the year since 2006 when it beat Detroit 9-6 in the regular-season opener. Seattle is 1-5 at Arizona since the Cardinals moved into their new stadium in Glendale, Ariz., in 2006. |
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| Week 2 |  | vs. Dallas Cowboys | Sunday, Sept. 16 | 1 p.m. |
Storyline: Seattle has lost three games to Dallas over the past four seasons by a combined score of 8595-39. However, all three games were played in Dallas. This is the first time since 2005 that Dallas will play in Seattle. Seattle is 2-8 vs. the NFC East over the previous four seasons. |
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| Week 3 |  | vs. Green Bay Packers | Monday, Sept. 24 | 5:30 p.m. |
| Storyline: Seattle's new quarterback is Green Bay's old backup, but that's not the only reason Matt Flynn will be centerstage in this game. The Packers led the league in scoring at 35 points last year. The Seahawks ranked No. 28 in overall offense, and they are going to be hard pressed to keep pace. |
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| Week 4 |  | at St. Louis Rams | Sunday, Sept. 30 | 10 a.m. |
| Storyline: Seattle has won 13 of its past 14 regular-season games against the Rams, and defeated St. Louis by a combined total of 54-20 in two meetings last year. |
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| Week 5 |  | at Carolina Panthers | Sunday, Oct. 7 | 1 p.m. |
| Storyline: Seattle is 0-2 at Carolina, which is one of only two NFL cities where the Seahawks have never won. Baltimore is the other. The Seahawks never played the Colts in Baltimore and are 0-2 on the road vs. the Ravens. |
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| Week 6 |  | vs. New England Patriots | Sunday, Oct. 14 | 1 p.m. |
| Storyline: Pete Carroll spent three seasons as Patriots coach before he was fired after the 1999 season. He remade himself as a football in nine seasons at USC and now faces his former franchise for the first time. |
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| Week 7 |  | at San Francisco 49ers | Thursday, Oct. 18 | 5:20 p.m. |
| Storyline: Seattle has lost three consecutive road games at San Francisco, none of those games decided by fewer than 13 points. |
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| Week 8 |  | at Detroit Lions | Sunday, Oct. 28 | 10 a.m. |
| Storyline: Seattle is 7-4 against Detroit since entering the league. |
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| Week 9 |  | vs. Minnesota Vikings | Sunday, Nov. 4 | 1 p.m. |
| Storyline: The Vikings have won the past two regular-season meetings against the Seahawks by a combined score of 66-22. |
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| Week 10 |  | vs. New York Jets | Sunday, Nov. 11 | 1 p.m. |
| Storyline: Seattle has lost eight of its last 10 regular-season games against the Jets going back to 1985, though the Seahawks did win the most recent matchup between the two teams, a 13-3 victory in 2008. |
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| Week 11 | BYE | | |
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| Week 12 |  | at Miami Dolphins | Sunday, Nov. 25 | 10 a.m. |
| Storyline: Seattle is 1-5 at Miami during the regular season, the Seahawks only regular-season road victory coming in 1990. |
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| Week 13 |  | at Chicago Bears | Sunday, Dec. 2 | 10 a.m. |
| Storyline: This is the sixth time in seven seasons the Seahawks and Bears will play in the regular season. They've also met twice in the playoffs in that time. This is the third year in a row the Seahawks play at Chicago, Seattle winning there each of the previous two regular-season meetings. |
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| Week 14 |  | vs. Arizona Cardinals | Sunday, Dec. 9 | 1:15 p.m. |
| Storyline: The Seahawks and Cardinals split their two-game regular-season series last year, and each game was decided by three points. |
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| Week 15 |  | vs. Buffalo Bills (in Toronto) | Sunday, Dec. 16 | 1 p.m. |
| Storyline: Buffalo has won the last two meetings between these teams by a combined score of 72-19, but this one is exported to Canada making a unique setting. |
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| Week 16 |  | vs. San Francisco 49ers | Sunday, Dec. 23 | 1:15 p.m. |
| Storyline: The 49ers' 19-17 victory at Seattle on Christmas Eve was a physical, tightly played contest between two teams, and the fact that one of San Francisco's coaches shouted, "Merry Christmas" as he walked through the press box to the elevator won't do anything to lessen the emotional intensity this time around. |
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| Week 17 |  | vs. St. Louis Rams | Sunday, Dec. 30 | 1:15 p.m. |
| Storyline: Seattle has won seven in a row at home vs. the Rams, and six of those seven consecutive home victories against St. Louis were by 10 points or more. The Rams have not won in Seattle since a 33-27 overtime victory in October 2004. |
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