Skip to main content

Originally published August 8, 2013 at 4:39 PM | Page modified August 8, 2013 at 5:11 PM

  • Share:
  • Comments (0)
  • Print

Experimental canine cancer drug promising, may be tried on humans

Most Popular Comments
Hide / Show comments
No comments have been posted to this article.
Start the conversation >


PAC-1, a drug that signals cancer cells to self-destruct, has shown promise for treatment of cancer in dogs at the University of Illinois Veterinary Teaching Hospital. Veterinary oncologist and trial coordinator Tim Fan says the drug was evaluated in dogs who had advanced blood or bone cancers that had metastasized to lung tissue.

Researchers say they plan to evaluate its use for treatment of brain cancer in humans. PAC-1 targets a cellular enzyme called procaspase-3 found at elevated levels in many forms of cancers, including those of the breast, colon, liver, lung, skin, blood and brain.

“It gives cancer cells a signal to commit suicide,” said Illinois chemistry Professor Paul Hergenrother, who discovered the drug in 2005.

Read full story here

Seattle Times staff

The Seattle Times

The door is closed, but it's not locked.

Take a minute to subscribe and continue to enjoy The Seattle Times for as little as 99 cents a week.

Subscription options ►

Already a subscriber?

We've got good news for you. Unlimited content access is included with most subscriptions.

Subscriber login ►