Skip to main content
Advertising

Originally published Saturday, March 1, 2014 at 2:09 PM

  • Share:
           
  • Comments (5)
  • Print

Baby’s brain tumor contained fully grown teeth

The tumor found in the child was a craniopharyngioma, a rare mass found mostly in young children that can press up against the pituitary gland and optic nerve and cause pressure in the brain, according to the National Institutes of Health.


The Baltimore Sun

Most Popular Comments
Hide / Show comments
Possibly a "Phantom Twin?" MORE
We may think we know all about embryology - normally things proceed in a well regulated... MORE
There are a number of scenarios where twins began but only one survived. ... MORE

advertising

BALTIMORE — Doctors at Johns Hopkins Hospital have removed a rare tumor that contained several fully grown teeth from a baby boy’s brain.

The tumor was found in the then-4-month-old from West Virginia in 2012 after a pediatrician noticed his head was unusually large for his age.

Doctors wrote about the findings in an article that appeared last week in The New England Journal of Medicine. The discovery could help researchers trying to cure diseases or grow new organs, medical experts said.

“It gives us more insight into the origins of the tumor,” said Dr. Edward Ahn, a pediatric neurosurgeon at Johns Hopkins who was the lead surgeon in the case.

The tumor found in the child was a craniopharyngioma, a rare mass found mostly in young children that can press up against the pituitary gland and optic nerve and cause pressure in the brain, according to the National Institutes of Health.

Only five other cases in medical literature found teeth in these types of tumors, Ahn said.

Teeth are more commonly found in another kind of tumor, teratomas. Doctors have found many bodily structures, including fingers and partially formed humans, in teratomas because their cells have the ability to form any kind of cell type or organ system within the tumor mass, said Dr. James Rutka, a pediatric neurosurgeon and chair of the University of Toronto’s department of surgery who was not involved in the Maryland case.

“If they are absolutely certain this is a craniopharyngioma, it would be way less common” to have teeth or any body part, said Rutka, editor-in-chief of the Journal of Neurosurgery and a past president of the American Association of Neurological Surgeons.

The baby’s mother, who did not want to be identified, said in an interview that she took her son to the pediatrician for a stuffy nose in 2012. Doctors discovered the boy’s head had grown significantly from two weeks before when it was measured during a routine visit.

An ultrasound and CT scan revealed the massive tumor, which doctors said they had to remove through surgery.

“The tumor was very large and the baby was so small,” Ahn said. “To do this type of surgery on a 4-month-old baby is extremely risky, but something we had to do right away.”

Until the surgery, doctors didn’t know what kind of tumor had grown in the child’s brain.

Once inside the brain, Ahn discovered a solid tumor with pieces of white that he thought at first was calcium, which is not unusual in these tumors.

Craniopharyngioma tumors are formed from the lining of the brain or back of the mouth and often have calcium inside but not organized into teeth, Rutka said.

“We had to think twice,” Ahn said. “We first thought they were flakes of calcium. When we looked at it closer, we were like, ‘Those really look like teeth.’ “

A pathologist confirmed a week later that they were teeth.

Ahn said more research is needed on craniopharyngioma tumors to determine why teeth sometimes form.

“No one knows,” he said. “It must be the origin of the tumor. ... They might have had some common lineage with the cells that produce teeth.”

Dr. Narlin Beaty, a neurosurgeon at the University of Maryland Medical Center who helped research and write the New England Journal of Medicine article, said the discovery could help build on current research and theories.

“It always has been hypothesized that this type of tumor is from cells that form teeth,” Beaty said. “We see calcification and keratin and other parts of teeth, but very rarely do we see fully formed teeth. Any time you see anything out of the ordinary in medicine, it is important to document it and you can learn from it.”

The boy is now 2 years old and walking. He has some vision problems and is on a hormone-replacement regimen, but has adjusted well since the surgery, his mother and Ahn said. Doctors could not remove all of the tumor because it was too close to major blood vessels. The boy comes for regular checkups at Hopkins so doctors can monitor his condition.

“The child is doing great,” Ahn said. “He is making good developmental progress. So far, so good.”



News where, when and how you want it

Email Icon

Meet the winemakers

Meet the winemakers

View video interviews, conducted by The Seattle Times wine writer Andy Perdue, profiling five of our state's top winemakers.

Advertising

Partner Video

Advertising

The Seattle Times Historical Archives

Browse our newspaper page archives from 1900-1984


Advertising
The Seattle Times

The door is closed, but it's not locked.

Take a minute to subscribe and continue to enjoy The Seattle Times for as little as 99 cents a week.

Subscription options ►

Already a subscriber?

We've got good news for you. Unlimited seattletimes.com content access is included with most subscriptions.

Subscriber login ►