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Originally published Monday, October 31, 2005 at 12:00 AM

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Some fear cervical cancer vaccine could encourage teen sex

A new vaccine that protects against cervical cancer has set up a clash between health advocates who want to use the shots aggressively to...

The Washington Post

WASHINGTON — A new vaccine that protects against cervical cancer has set up a clash between health advocates who want to use the shots aggressively to prevent thousands of malignancies and social conservatives who say immunizing teenagers could encourage sexual activity.

Although the vaccine will not become available until next year at the earliest, activists on both sides have begun maneuvering to influence how widely the immunizations will be employed.

Groups working to reduce the toll of the cancer are eagerly awaiting the vaccine and want it to become part of the standard roster of shots that children, especially girls, receive just before puberty.

Because the vaccine protects against a sexually transmitted virus, many conservatives oppose making it mandatory, citing fears that it could send a subtle message condoning sexual activity before marriage. Several leading groups that promote abstinence are meeting this week to formulate official policies on the vaccine.

Officials from the companies developing the shots — Merck & Co. and GlaxoSmithKline — have been meeting with advocacy groups to try to assuage their concerns.

The jockeying reflects the growing influence that social conservatives have gained on a broad spectrum of policy issues under the Bush administration. In this case, a former member of the conservative group Focus on the Family serves on the federal panel that is playing a pivotal role in deciding how the vaccine is used.

"What the Bush administration has done has taken this coterie of people and put them into very influential positions in Washington," said James A. Morone Jr., a professor of political science at Brown University. "And it's having an effect in debates like this."

The vaccine protects women against strains of a ubiquitous germ called the human papilloma virus. Although many strains of the virus are innocuous, some can cause cancerous lesions on the cervix (the outer end of the uterus), making them the primary cause of this cancer in the United States. Cervical cancer strikes more than 10,000 U.S. women each year, killing more than 3,700.

The vaccine appears to be virtually 100 percent effective against two of the most common cancer-causing HPV strains. Merck, whose vaccine is further along, plans to ask the Food and Drug Administration by the end of the year for approval to sell the shots.

Exactly how the vaccine is used will be largely determined by the Advisory Committee on Immunization Practices (ACIP), a panel of experts assembled by the Centers for Disease Control and Prevention in Atlanta.

The panel issues widely followed guidelines, including recommendations for childhood vaccines that become the basis for vaccination requirements set by public schools.

Officials of both companies noted that research indicates the best age to vaccinate would be just before puberty, to make sure young people are protected before they become sexually active. The vaccine would probably be targeted primarily at girls but could also be used on boys to limit the spread of the virus.

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"If you really want to have cervical-cancer rates fall as much as possible as quickly as possible, then you want as many people to get vaccinated as possible," said Mark Feinberg, Merck's vice president of medical affairs and policy, noting that "school mandates have been one of the most effective ways to increase immunization rates."

That is a view being pushed by cervical-cancer experts and women's health advocates.

"I would like to see it that if you don't have your HPV vaccine, you can't start high school," said Juan Carlos Felix of the University of Southern California in Los Angeles, who leads the National Cervical Cancer Coalition's medical advisory panel.

At the ACIP meeting last week, panel members heard presentations about the pros and cons of vaccinating girls at various ages.

A survey of 294 pediatricians presented at the meeting found that more than half were worried that parents of female patients might refuse the vaccine, and 11 percent of the doctors said they thought vaccinating against a sexually transmitted disease "may encourage risky sexual behavior in my adolescent patients."

Conservative groups say they welcome the vaccine as an important public-health tool but oppose making it mandatory.

"Some people have raised the issue of whether this vaccine may be sending an overall message to teenagers that we expect you to be sexually active," said Dr. Reginald Finger, who served as a medical analyst for Focus on the Family before being appointed to the ACIP in 2003.

"There are people who sense that it could cause people to feel like sexual behaviors are safer if they are vaccinated and may lead to more sexual behavior because they feel safe," said Finger, emphasizing that he does not endorse that position and is withholding judgment until the issue comes before the vaccine policy panel for a formal recommendation.

Conservative medical groups have been fielding calls from concerned parents and organizations, officials said.

"I've talked to some who have said, 'This is going to sabotage our abstinence message,' " said Gene Rudd, associate executive director of the Christian Medical and Dental Associations.

But Rudd said most people change their minds once they learn more, adding that he would probably want his children immunized. Rudd, however, draws the line at making the vaccine mandatory.

"Parents should have the choice. There are those who would say, 'We can provide a better, healthier alternative than the vaccine, and that is to teach abstinence,' " Rudd said.

Both companies said they have been working to alleviate the concerns by meeting with groups across the political spectrum.

Alan Kaye, executive director of the National Cervical Cancer Coalition, likened the vaccine to wearing a seat belt.

"Just because you wear a seat belt doesn't mean you're seeking out an accident," Kaye said.

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